The CCFC Grants in Aid of Research program is intended to support research on finding a cure for inflammatory bowel disease (IBD). Grants are awarded to investigators working alone or in collaboration with others. Grants will be awarded for a maximum of three years, not to exceed $125,000 per annum.
We were able to fund 11 promising research applicants from a pool of 42 proposals we received through the Grants In Aid of Research and Strategic Priority Partnership Initiative competitions. Click HERE to read summaries on this year's grants.
|
Name |
Title of Research |
Period of Funding |
Paul Beck
University of Calgary |
The NLRP3-inflammasome is a key regulator of intestinal homeostatis |
2010-2013 |
Francois Boudreau
University of Sherbrooke |
Blocking inflammatory genes expression during inflammatory bowel disease |
2010-2013 |
Stephen Girardin
University of Toronto |
The NOD-like receptor IL-22 signaling pathway in the defense of the intestinal lining |
2010-2013 |
Paul Kubes
University of Calgary |
Role of the Adapter Molecule MyD88 and the Protein Molecule TRIF in IBD |
2010-2013 |
Dana Philpott
University of Toronto |
Nod proteins in intestinal homeostasis |
2010-2013 |
Nathalie Rivard
University of Sherbrooke |
Role of the phosphate-removing enzyme, SHP-2, in intestinal inflammation |
2010-2013 |
Marika Sarfati
Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) |
Characterization of disease-causing dendritic cells in Crohn's disease |
2010-2013 |
Mark Silverberg
Mount Sinai Hospital |
Genetic markers of outcomes in Crohn's disease |
2010-2013 |
Bruce Vallance
University of British Columbia |
Modeling Intestinal Fibrosis in Crohn's Disease |
2010-2013 |
Stephen Vanner
Queen’s University |
Investigation of new pain targets for treating patients with inflammatory bowel disease |
2010-2013 |
Elena Verdu
McMaster University |
Sensing of microflora and colitis |
2010-2013 |
Premysl Bercik
McMaster University |
Intestinal microbiota and the increased sensitivity to colitis in depression
Intestinal Microbiota and the Increased Sensitivity to Colitis in Depression |
2009-2012 |
Kenneth Croitoru
University of Toronto |
Studies of the induction and regulation of colitis in a mouse model
Studies of the induction and regulation of colitis in a mouse model
All That Glitters Gala, Toronto, Grant in Aid of Research |
2009-2012 |
Fernand-Pierre Gendron
Universite de Sherbrooke |
Re-visiting P2Y nucleotide receptors as a cure for IBD
Role of epithelial cells P2Y receptors in the dysfunction of the intestinal mucosa during inflammation |
2009-2012 |
Alan Lomax
Queen's University |
Neuroimmune interactions during inflammatory bowel diseases
Sympathetic neuropathy in IBD: causes and consequences
|
2009-2012 |
Karen Madsen
Univesirty of Alberta |
Bacterial DNA and gut function
Bacterial DNA and gut homeostasis |
2009-2012 |
Derek McKay
University of Calgary
|
The inhibition of colitis by helminth infection
Helminth Infection, Alternatively Activated Macrophages and the Inhibition of Colitis |
2009-2012 |
David Sigalet
Alberta Children's Hospital |
Immune signaling pathways of the GLP2 protein in the inflamed intestine
Immune Signaling Pathways of Glugacon Like Peptide 2 in the Inflamed Intestine
M&M Meat Shops Grant in Aid of Research |
2009-2012 |
Emma Allen-Vercoe
University of Guelph
|
Does a disease-causing bacterium from the mouth also cause problems in the gut for IBD patients?
Interactions of Fusobacterium nucleatum with intestinal epithelial cells: Implication for disease exacerbation in IBD
The Grocery Foundation Grant in Aid of Research |
2009-2012 |
Claude Asselin
University of Sherbrooke |
The intestinal epithelial cell response to inflammation
Role of C/EBP transcription factors and deacetylation in intestinal inflammation |
2008-2011
Summary
Progress Report 1
|
Michael Blennerhassett
Queen’s University |
Why does inflammation cause nerve damage in IBD, and how can we prevent this?
Neuronal survival and axon regeneration in intestinal inflammation |
|
Richard Fedorak
University of Alberta |
Finding a urine test that will diagnose IBD
The IBD Metablome Project: NMR Metabolic Analysis to Identify IBD and the microbe-genetype Relationship
Electronics Industry Hockey Tournament Innovations in IBD Research Award |
|
Brett Finlay
University of British Columbia |
The role of inflammation and the microbiota using different models: Exploring the interplay between host and microbiota during colitis
The role of the microbiota in infectious colitis and fibrosis |
|
Scott Gray-Owen
University of Toronto |
Tickling the receptor: Defining how bacteria linked to Crohn's disease penetrate the gut surface
AIEC engagement of CEACAM6: Defining the link to Crohn's disease
Federated Health Charities’ Grant in Aid of Research |
2008-2011
Summary
Progress Report 1 |
Nicola Jones
Hospital for Sick Children |
Determining how the ATG16L1 gene favors the development of Crohn disease
The role of ATG16L1 in Crohn's disease |
2008-2011
Summary
Progress Report 1 |
Waliul Khan
McMaster University |
How the hormone serotonin influences gut inflammation
Endocrinological regulation of gut inflammation by serotonin (5-hydroxytryptamine; 5-HT) |
2008-2011
Summary
Progress Report 1 |
Wallace MacNaughton
University of Calgary |
Role of proteases and their receptors in IBD
Mechanisms of protease-induced inflammation in IBD |
|
Elaine Petrof
Queen’s University |
Use of probiotic products as a strategy to block intestinal inflammation
Effect of probiotic conditioned media on a mouse model of inflammatory colitis
Fay Shapiro Cutler Legacy Grant
|
|
Mark Silverberg
Mount Sinai Hospital |
Inherited and environmental factors that contribute to the development of inflammation of the pouch after surgery for ulcerative colitis
Genetic, serological, and microbial factors related to patterns of illeal Inflammation |
2008-2011
Summary
Progress Report 1 |
Laura Sly
Child and Family Research Institute |
Altering immune cell function in inflammatory bowel disease
Macrophage phenotype in inflammatory bowel disease
M&M Meat Shops Legacy Grant |
|
Martin Storr
University of Calgary |
Treatment of IBD with cannabinoids, looking for a cure
Cannabinoids in colitis
Healthpartners Grant in Aid of Research |
2008-2011
Summary
Progress Report 1 |
Ali Ahmad
St. Justine Hospital |
Role of NK Receptors and their Ligands in the immunopathogenesis of Crohn’s Disease
M&M Meat Shops Grant in Aid of Research |
2007-2010
Progress Report 1
Progress Report 2 |
François Boudreau
Universite de Sherbrooke |
Role of Transcriptional Effectors of the TGFB Superfamily During Intestinal Inflammatory Response
The Grandey Family Foundation Grant in Aid of Research
|
2007-2010
Progress Report 1
Progress Report 2 |
Andre G. Buret
University of Calgary |
Disruptions of epithelial integrity in the pathogenesis of IBD: The effects of C. jejuni. |
2007-2010
Progress Report 1
Progress Report 2 |
Kris Chadee
University of Calgary |
Role of prostaglandin E(2) in modulating epithelial barrier function |
2007-2010
Progress Report 1
Progress Report 2 |
Jeroen Marc Daniel De Buck
University of Calgary |
Proteomic identification of human and animal Mycobacterium avium subsp. Paratuberculosis strains by mass spectrometry |
|
Christophe Faure
Sainte-Justine Hopital |
Regulation and role of PSA-NCAM in enteric nervous system in TNBS-induced colitis |
|
Richard Fedorak
University of Alberta |
The IBD Metabolome Project: NMR Metabolomic Analysis to Identify IBD and the Microbe-Genotype Relationship |
2007-2008
|
Stephen Girardin
University of Toronto |
New insights into the detection of peptidoglycan by Nod2/CARD15: implications for Crohn’s disease |
|
Kevan Jacobson
BC’s Children’s Hospital |
Intestinal Barrier Responses, neuropeptides and IBD |
|
Denis Krause
University of Manitoba |
Role of Bacteroides spp. and Escherichia coli in inflammatory bowel disease
All That Glitters Gala, Winnipeg, Grant in Aid of Research |
2007-2010
Progress Report 1
Progress Report 2 |
Andrew James Macpherson
McMaster University |
Mechanisms of normal intestinal lamina propria CD4 responses that ensure mutualism with commensal intestinal bacteria |
|
Robin McLeod
Mount Sinai Hospital |
Post Operative Recurrence in paediatric Crohn’s disease: Influence of Molecular Factors |
2007-2010
Progress Report 1
Progress Report 2 |
Mark Ropeleski
Queen’s University |
Intestinal Epithelial anti-apoptotic signalling and healing: novel roles for IL-11 in inflammation |
2007-2010
Progress Report 1Progress Report 2 |
Philip Sherman
Hospital for Sick Children |
Role of Probiotics in the management of experimental inflammatory bowel diseases
Fay Shapiro Cutler Grant in Aid of Research |
2007-2010
Progress Report 1
Progress Report 2 |
Katherine Siminovitch
Mt Sinai Hospital |
Characterization of susceptibility genes/molecules for inflammatory bowel disease
The Kerry and Simone Vickar Family Foundation Grant in Aid of Research |
2007-2010
Progress Report 1
Progress Report 2
|
Bruce Vallance
University of British Columbia |
Goblet Cell Mediators and their Impact on Mucosal Protection and Susceptibility to Colitis |
2007-2010
Progress Report 1
Progress Report 2 |
Stephen Vanner
Queen’s University |
Novel Pain Mechanisms in IBD |
|
John Wallace
University of Calgary |
Resolution of Colitis: A Translational Study |
|
Emma Allen-Vercoe
University of Guelph |
Association of Fusobacterium nucleatum infection with IBD: host and bacterial interactions |
2006-2009
Progress Report 2
Final Report |
Fernand-Pierre Gendron
Universite de Sherbrooke |
Modulation of the intestinal epithelial cell Immune responses by the P2Y2 receptor in IBD
Colette and Adam Grosvenor Grant in Aid of Research |
|
Paul Kubes
University of Calgary |
Regulatory T cells and Inflammatory Bowel Disease |
2006-2009
Final Report
|
Alan Lomax
Queen’s University |
Neural regulation of the gastrointestinal microvasculature during colitis
Fay Shapiro Cutler Grant in Aid of Research
|
|
John MacLeod
Queen’s University |
Extracellular calcium-sensing receptor stimulates IL-11 secretion which repairs damaged intestinal barrier functions |
|
Wallace MacNaughton
University of Calgary |
Inflammation-induced changes in intestinal epithelial aquaporin expression.
M&M Meat Shops Grant in Aid of Research |
2006-2009
Progress Report 2
Progress Report 3 |
Karen Madsen
University of Alberta |
Interactions between bacteria and toll-like receptor 9 |
2006-2009
Progress Report 2
Final Report |
Derek McKay
University of Calgary |
Inhibition of Colitis by Infection with Parisitic Helminths: Participation of Regulatory T Cells and Macrophages |
2006-2009
Progress Report 2
Final Report |
Kevin Rioux
University of Calgary |
Molecular analysis of the effects of mesalamine on the intestinal microbiota and relevance to anti-inflammatory and cancer chemoprophylactic activity |
2006-2009 Progress Report 1 |
Andrew Stadnyk
Dalhousie University |
Blocking PMN transepithelial migration controls inflammation |
2006-2009
Progress Report 2
Final Report |
Theodore Steiner
University of British Columbia |
Role of Bacterial Flagellin as an Inflammatory Stimulus in Inflammatory Bowel Disease |
2006-2009
Progress Report 2
Final Report |
Nathalie Vergnolle
University of Calgary |
Involvement of thrombin receptors in mechanisms of colon inflammation |
|
Pierre-Yves von der Weid
University of Calgary |
Role of cyclooxygenase metabolites in inflammation-induced lymph flow alteration in an animal model of IBD |
2006-2009
Progress Report 2
Final Report |
